Depression Research Study
Researchers at the University of Texas Southwestern Medical Center are conducting a study to learn more about the brain and possible depression treatments in individuals currently suffering from depression.
Fast Facts
Currently Experiencing Depressive Symptoms
Ages 18-65
Compensation Provided
Conducted in Dallas, TX
Study Background
Researchers at UT Southwestern Medical Center are looking for adults currently suffering from depression to participate in a 5-week clinical trial.
In this research study, we want to learn if changes in the neurocircuit (an arrangement of neurons and their interconnections) can affect irritability in people currently suffering from depression.
Over the course of the 5-week clinical trial, participants will attend 7 study visits, each lasting approximately 4 hours. Participants will be randomly assigned into groups to receive either intravenous (IV) ketamine or midazolam infusions during 4 of the visits.
If you are an adult currently experiencing depressive symptoms, we invite you to apply to this compensated study!
Study Background
Researchers at UT Southwestern Medical Center are looking for adults currently suffering from depression to participate in a 5-week clinical trial.
In this research study, we want to learn if changes in the neurocircuit (an arrangement of neurons and their interconnections) can affect irritability in people currently suffering from depression.
Over the course of the 5-week clinical trial, participants will attend 7 study visits, each lasting approximately 4 hours. Participants will be randomly assigned into groups to receive either intravenous (IV) ketamine or midazolam infusions during 4 of the visits.
If you are an adult currently experiencing depressive symptoms, we invite you to apply to this compensated study!
Additional Information
The goal of this research study is to understand more about how changes in neurocircuitry (an arrangement of neurons and their interconnections) may affect irritability in people currently suffering from depression.
You may qualify for this study if you meet the following criteria.
Inclusion Criteria:
Ages 18-65
Currently experiencing depressive symptoms
No diagnosis of schizophrenia or bipolar disorder
Weigh less than 265 lbs
Willing to participate in brain scans before and after receiving the infusions of the study drug
Have been adequately treated for sleep apnea
Able to undergo MRI scan (no metal in the body, no claustrophobia, must be able to lie still for 1+ hours)
If taking psychiatric medication, have been on stable dose for the past 4 weeks
Over the course of this 5-week research study, participants will come in for 7 total visits, each lasting approximately 4 hours. Participants will be randomly assigned into groups to receive either intravenous (IV) ketamine or midazolam infusions during four of the visits.
The schedule of visits is as follows:
- Screening visit
- Baseline visit including an MRI
- IV ketamine/midazolam infusion
- IV ketamine/midazolam infusion
- IV ketamine/midazolam infusion
- IV ketamine/midazolam infusion
- Study Exit visit including an MRI
If a participant is receiving a ketamine infusion, they will need to be driven to and from the appointment. If they are unable to do so, we can arrange travel for the infusion visits.
Compensation is provided to all participants.
There is no cost for you to enroll in this registry.