This clinical trial is being conducted to better understand how an investigational vaccine may help prevent Clostridioides difficile (C. diff) infection in adults aged 65 and older who may be at increased risk of infection. Researchers hope to learn whether the vaccine is safe and effective at reducing the risk of developing C. diff and its related health complications.

You may be eligible for this trial if you meet the following criteria.

• Aged 65+
• Have had frequent doctors visits or have been hospitalised within the last year
• Meet at least one of the following criteria:

• • Have been hospitalised within the last 12 months
  • Have visited A&E two or more times within the last 12 months
  • Have taken antibiotics within the last 12 weeks
  • Have a planned hospital admission or elective surgery

Overall Duration

This trial may last up to 3.5 years. The trial will end when researchers have enough information to determine whether the investigational vaccine helps prevent Clostridioides difficile (C. diff) infection.

In-Person Trial Activities

• Participants will visit the trial site at least 5 times during the trial.
• During these visits, participants will meet with the trial doctor and research staff and complete clinical trial-related procedures. These procedures may include blood work, height and weight measurements, and other health assessments related to the trial.

Remote Activities

• Some trial visits will take place remotely by phone or video call.
• During these remote visits, participants will speak with the trial doctor about their health and any updates related to their participation in the trial.

Participants may receive compensation for their time. Transportation support may be provided, and travel expenses may be reimbursed for clinical trial-related visits.

There is no cost for you to participate in our clinical trial.