Depression
Research Study

Women experience depression during pregnancy more often than many people realize, but not everyone feels comfortable using medication or is able to access effective treatment. Untreated depression during pregnancy can affect both the pregnant person and the baby, including increased risks for postpartum depression and pregnancy complications.

Fast Facts

Ages 18+

Less than 32 weeks (8 months) pregnant

Compensation
provided

Conducted in
The Greater Toronto Area

Additional Information

This study is being conducted to better understand depression during pregnancy and to explore whether at-home transcranial direct current stimulation (tDCS), a non-drug treatment option, can safely improve depression symptoms and overall well-being during and after pregnancy.

You may be eligible for this study if you meet the following criteria.

Inclusion Criteria:

  • Age 18 or older
  • Currently pregnant and less than 32 weeks (8 months) pregnant
  • Experiencing moderately severe to severe depression symptoms
  • Not taking antidepressant medication to treat depression symptoms 
  • Have not started or changed depression treatment within the last month
  • Able to complete study activities in English

Exclusion Criteria:

  • Active alcohol or substance use disorder
  • Diagnosis of bipolar disorder, schizophrenia, or another psychotic disorder
  • History of seizures 
  • Major unstable or life-threatening medical conditions
Overall Duration

This study includes a 3-week treatment period during pregnancy, followed by check-ins throughout the rest of the pregnancy and up to 52 weeks after delivery. Participation includes mostly remote activities. 

 
In-Person Activities

Participants will complete one in-person visit at either Women’s College Hospital or Sunnybrook Health Sciences Centre, in Toronto, Ontario. During this visit, the research team will:

  • Guide participants through their first transcranial direct current stimulation (tDCS) treatment session

 

Participants may also complete interviews, questionnaires, and mental health assessments during the study. All assessments may be completed by phone or online. No blood draws are required for this study.

 

At-Home Activities

As long as participants can complete the first session in person, they can take the device home and self-administer the rest of the sessions: 

  • Self-administer 15 at-home tDCS treatment sessions over 3 weeks, complete one 30-minute treatment session per weekday (5 days per week), and attend short video monitoring visits with study staff during treatment sessions. 

 

After the treatment phase, participants will complete follow-up assessments approximately every 4 weeks during pregnancy and again at 4, 12, 26, and 52 weeks after delivery.

Information collected during the study will be kept confidential and securely stored. Video visits are used only for study monitoring and support.

Participants may receive up to $190 in gift cards as a token of appreciation for completing study assessments. Participants will also be reimbursed for transportation and parking. 

There is no cost for you to participate in our research study.