The purpose of this research study is to investigate whether the smoking medication varenicline and financial incentives can help individuals in their journey to quit using e-cigarettes.

You may qualify for this study if you meet the following criteria.

Inclusion Criteria:

• Ages 18-40
• Use e-cigarettes daily or near daily and are interested in quitting
• Used cannabis in the past 30 days
• Do not smoke cigarettes regularly
• No serious or unstable medical/psychiatric disorder (including severe substance use disorders other than cannabis or tobacco use disorders) in the past 3 months
• Not currently pregnant, breastfeeding, or refusing to use an appropriate form of birth control
• No current use of medications for smoking cessation
• Willing to take varenicline for the standard 12-week course of treatment
• Able to attend study visits at one of the following sites: Charleston, Lancaster, or Pickens, SC

This study will last about 6 months and includes 17 in‑person study visits.

For 12 weeks, you will receive medication and counseling as part of the study treatment.

You may receive varenicline, which is FDA‑approved for cigarette cessation, but not yet FDA‑approved for e‑cigarette cessation.

As a participant, you can receive up to $1,050 for completing all study tasks.

There is no cost for you to participate in our research study.