The purpose of this study is to investigate how e-cigarettes, nicotine replacement therapy, and varenicline can help people reduce their harm from cigarettes.

You may be eligible for this study if you meet the following criteria.

Inclusion Criteria:

• Men ages 21+
• Daily cigarette smoker
• Interested in reducing cigarette use
• Have tried to quit in the past year (using patches, gums, nasal sprays, lozenges, etc.)

Exclusion Criteria:

• Planning to move out of South Carolina
• Currently pregnant, breastfeeding, or trying to become pregnant

This study involves an online screening, 13 phone calls over 6 and a half months, and daily smoking diaries for 10 weeks. Participants will also have the opportunity to try e-cigarettes, nicotine replacement therapy (such as patches and lozenges), or varenicline (Chantix) to support their efforts to reduce their cigarette use.

Participants in this study may receive compensation up to $860.

There is no cost for you to participate in our research study.