This study is being done to see if a hydration program for people taking GLP-1 medications who have a history of kidney stones can be delivered successfully. The results will help researchers determine whether the program is practical to use in a larger study.

You may be eligible for this study if you meet the following criteria.

Inclusion Criteria:

• History of a kidney stone diagnosis
• Have obesity (BMI of 30 or higher)
• Currently taking a GLP-1 medication (such as Wegovy, Ozempic, Mounjaro, Zepbound, Trulicity, or Rybelsus)
• Ages 18+
• Have trouble meeting the recommended 2.5 L (or 84.5 fl. oz) of urine daily
• Living in the continental US
• Own a smartphone
• Willing to participate in a 6-month-long study that involves 4 Zoom meetings and virtual urine collections

Exclusion Criteria:

• History of a cystine kidney stone
• Currently enrolled in another study involving fluid intake
• Planning surgery in the next 6 months
• Any medical condition that restricts fluid intake

This is a fully virtual study, and participation will take about 6 months. If you qualify and choose to participate:

1. Complete the initial assessments: You will complete surveys, rate your thirst through text messages for 7 days, measure your weight and blood pressure, and collect a 24-hour urine sample using a kit delivered to your home.
2. Join an enrollment Zoom: After your initial assessments, you will be randomly assigned to one of two groups, similar to a coin flip. During a Zoom visit, study staff will provide education about hydration and help you set up your study devices.
3. Use the smart water bottle and app: One group will use a smart water bottle and app to track fluid intake and receive text reminders when fluid intake is below the hourly goal. The other group will receive the smart water bottle and app after completing the 6-month assessments.
4. Complete follow-up assessments: At about 3 and 6 months, you will repeat surveys, thirst ratings, weight and blood pressure measurements, and 24-hour urine collection. Urine collection kits will be delivered to your home and returned to the lab.
5. Share your experience: You may also be invited to participate in interviews about your experience with the program.
   
   

All study activities are completed remotely from home using Zoom, email, phone, and text messages.

You may receive up to $150 for completing all study assessments.

There is no cost for you to participate in our research study.