Through this study, researchers at Temple University want to learn more about trajectories of reward responsiveness, inflammation, and emotion systems in teens.

You may be eligible for this study if you meet the following criteria.

Inclusion Criteria:

• Ages 13-16
• Experiencing extremely low motivation and/or ambition (e.g., decreased interest in previously enjoyed activities, goal-setting difficulties, persistent boredom or apathy)
• Located near Philadelphia, PA
• No current psychotic symptoms (hallucinations, delusions)
• No autism spectrum disorder
• No history of cancer, heart disease, surgery, autoimmune disease, or disorder involving chronic inflammation
• Not HIV positive
• Not taking immunosuppressant medications (e.g., an inhaler, systemic steroids, prescription nonsteroidal anti-inflammatory drugs)
• Able to undergo MRI scan (no metal in the body, traumatic brain injury, pregnancy, or severe claustrophobia)

This study involves 3 in-person visits and 5 remote visits over the course of 3 years.

In the lab

• Participants will complete an in-person visit once a year, which includes blood tests, self-reported behavioral measures, and fMRI scans of reward neural activity and functional connectivity.

At home

• Participants will complete questionnaires and a remote interview asking them about their life events and mood. These will occur a few days prior to their yearly in-person sessions, as well as at the 6-month timepoints in between their in-person sessions, for a total of 5 remote sessions across the 3 years.
• Participants will also be asked to wear an Actiwatch for one week following the in-person sessions and complete daily questionnaires about their sleep.

As a participant, you can receive up to $750 for your time and effort.

You will receive $650 for completing the entire 3-year study with a bonus of up to $100 for completing all components ($90 for completing 90%, etc.)

There is no cost for you to participate in our research study.