Researchers at McLean Hospital, a Harvard Medical School affiliate, are studying how a nociceptin antagonist medication affects approach/avoidance decision-making and brain activity in adults with current depression and/or PTSD symptoms.

You may be eligible for this study if you meet the following criteria.

Inclusion Criteria:

• Ages 18-45
• Currently experiencing depression or PTSD symptoms
• Right-handed
• If female, not currently pregnant or breastfeeding
• Own a smartphone
• Able to undergo MRI (no claustrophobia, no metal in the body)

Exclusion Criteria:

• Currently taking any psychiatric medications
• History of seizures or seizure disorder
• Diagnosed with OCD, Autism, schizophrenia/psychotic disorders, bipolar disorder, severe borderline or antisocial personality disorder
• Diagnosis of anorexia
• Diagnosis of diabetes

Enrollment & Screening

• Informed consent, surveys, and a clinical interview with a study clinician

Randomization

• Randomized 1:1 to receive the study medication (BTRX-246040) or a placebo

fMRI Session

• Surveys, a structural and functional MRI exam, and behavioral tasks
• Two free smartphone apps installed for 3 weeks of surveys and passive data collection

6- and 12-Month Follow-Up Visits

• Clinical assessment and surveys with the study’s clinician
• The same two apps used again for 3 weeks after each follow-up

Participants may receive at least $521 if all components are completed, and up to $856 total.

There is no cost for you to participate in our research study.