Schizophrenia Paid
Research Study
Help researchers at Stony Brook University better understand the brain chemistry that affects thinking and symptoms of psychosis in adults with schizophrenia and schizoaffective disorder
Fast Facts
New York residents aged 18–55 who are diagnosed with schizophrenia or schizoaffective disorder
Have no other medical or neurological conditions
Compensation
provided
In-person study procedures at Stony Brook, NY (on Long Island). Transportation provided.
Study Background
Schizophrenia is a brain disorder that can affect how a person thinks, feels, and experiences the world. Current medications mainly target a brain chemical called dopamine, but many people still struggle with symptoms such as hallucinations, confusion, or memory problems. Researchers are now studying another important brain system—the cholinergic system—which is involved in memory, attention, and learning.
This study at Stony Brook University is exploring how this system may be linked to symptoms of schizophrenia. Participants will complete brain imaging (MRI and PET scans) and simple thinking tests to help researchers see how a protein called VAChT, which controls acetylcholine activity, works in the brain. By comparing results from people with and without schizophrenia, this research may help lead to new and better treatments in the future.
Study Background
The purpose of this study is to gain a deeper understanding of thinking and decision-making in individuals with schizophrenia.
Researchers at Stony Brook University aim to develop improved treatments for schizophrenia by examining how the disorder affects memory. This study will help researchers understand working memory in schizophrenia, which may lead to new ways to address the cognitive challenges associated with the condition.
Additional Information
This study is being done to better understand how a specific brain chemical system may be involved in the symptoms of schizophrenia. By using advanced brain imaging (MRI and PET scans), researchers at Stony Brook University aim to see how a protein that helps regulate brain communication may relate to thinking and memory problems in schizophrenia. Learning more about this system could help guide the development of new and more effective treatments in the future.
You may be eligible for this study if you meet the following criteria.
Inclusion Criteria:
Adults 18–55 years old
Live in NY
Fluent in English
Able to safely have an MRI and PET scan
Diagnosis of schizophrenia or schizoaffective disorder and/or experiencing symptoms of psychosis
Able to provide informed consent
Exclusion Criteria:
Serious medical or neurological condition (such as stroke, seizure disorder, or major head injury)
Currently pregnant or breastfeeding
Metal implants, pacemakers, or other MRI contraindications
Major psychiatric conditions (e.g., PTSD, OCD, borderline personality)
If you decide to take part, here’s what you can expect:
Screening visit: You’ll complete questionnaires, a brief medical exam, and safety checks (including urine and blood tests) to confirm eligibility.
Cognitive testing: You’ll do short memory and thinking tasks with a study team member.
MRI scan: You’ll have a noninvasive brain scan to look at brain structure and function.
PET scan: You’ll receive a small amount of a safe radioactive tracer through an IV, followed by a brain scan to study brain chemistry.
Follow-up: A study clinician will check in with you by phone after the scan to make sure you’re feeling well.
All procedures are done at Stony Brook University.
Participants can receive up to $530 for their time and effort.
There is no cost for you to participate in our research study.