In this research study, Baylor College of Medicine aims to better understand treatment-resistant bipolar depression by examining brain circuits involved in mood, motivation, and reward. Symptoms such as anhedonia may be linked to disruptions in these brain systems. This study uses neuroscience-guided approaches, including investigational treatments, to better understand and potentially improve depressive symptoms. Findings from this research may help inform future treatment options for individuals with treatment-resistant bipolar depression.

You may be eligible for this study if you meet the following criteria.

Inclusion Criteria:

• Adults aged 22–64
• Diagnosed with Bipolar I Disorder
• Have not responded to at least 4 prior treatments for bipolar depression, including 2 treatments during the current depressive episode
• Currently taking a mood stabilizer (e.g., lithium)

Exclusion Criteria:

• Schizophrenia or other psychotic disorders
• Current alcohol or substance use disorder
• Pregnancy
• Inability to undergo MRI (e.g., claustrophobia, non-removable metal in body)

• The entire study lasts approximately 20 months. Once enrolled, participation involves:

  In the clinic:

  • About 23 study visits, including medical, psychiatric, and cognitive evaluations.
  • The treatment involves Deep Brain Stimulation (DBS), a surgical procedure that is also used to treat other neurological and psychiatric conditions, including treatment-resistant Parkinson’s disease and obsessive-compulsive disorder (OCD).
  • Some study visits will involve adjustment of the device by the study psychiatrist to optimize treatment.
  • Assessments include interviews, questionnaires, neuropsychological testing, and MRI scans.
  • Certain visits will require a 24-hour stay at the Menninger NeuroBehavioral Monitoring Unit (NBU), which will be covered by the study team.
  • The first visit also includes a blood draw.

  At home / remote monitoring:

  • Participants will complete app-based assessments tracking mood, behavior, and daily experiences.
  • You may be asked to complete short surveys several times per day for specific periods during the study.
  • Surveys take less than 5 minutes each, and the app may collect behavioral data to better understand mood and daily functioning.

As a participant, you will be compensated for your time and participation. 

There is no cost for you to participate in our research study.