Older Adults Research Study
Researchers at the University of Oklahoma Health Sciences Center are conducting a study in older adults to understand how a form of Vitamin B3 may support brain and vascular health.
Fast Facts
Identify as a person of color (Asian, Black, Latino)
60-85
Years Old
Compensation
Provided Up To $200
Conducted in
Oklahoma City, OK
Study Background
Researchers at the University of Oklahoma Health Sciences Center are studying whether daily Vitamin B3 (nicotinamide riboside) supplementation can enhance brain function, memory, and vascular health in older adults.
Age-related declines in memory, energy, and vascular function may be linked to reduced levels of NAD⁺, a molecule essential for cellular energy, DNA repair, and healthy brain and blood vessel activity. Nicotinamide riboside (NR), a form of vitamin B3, has shown promise for safely boosting NAD⁺ levels and supporting brain and vascular health. In this study, we aim to learn whether daily NR supplementation can improve blood flow, brain activity, and cognitive function in older adults. We also want to better understand how changes in the body’s vascular and neurovascular systems relate to healthy aging and overall cognitive performance.
Ultimately, the findings from this study may help identify new, non-invasive approaches to support brain health and memory in older adults.
Study Background
Researchers at the University of Oklahoma Health Sciences Center are studying whether daily Vitamin B3 (nicotinamide riboside) supplementation can enhance brain function, memory, and vascular health in older adults.
Age-related declines in memory, energy, and vascular function may be linked to reduced levels of NAD⁺, a molecule essential for cellular energy, DNA repair, and healthy brain and blood vessel activity. Nicotinamide riboside (NR), a form of vitamin B3, has shown promise for safely boosting NAD⁺ levels and supporting brain and vascular health. In this study, we aim to learn whether daily NR supplementation can improve blood flow, brain activity, and cognitive function in older adults. We also want to better understand how changes in the body’s vascular and neurovascular systems relate to healthy aging and overall cognitive performance.
Ultimately, the findings from this study may help identify new, non-invasive approaches to support brain health and memory in older adults.
Additional Information
Nicotinamide riboside, a form of Vitamin B3 that boosts NAD⁺ levels, plays an important role in cellular energy, DNA repair, vascular health, and brain function. In this study, we aim to learn more about whether restoring NAD⁺ levels can support healthy aging by improving blood vessel function, brain activity, and cognitive performance in older adults. We also want to understand early changes in vascular and neurological health so that we can identify ways to help adults maintain strong cognitive functioning and overall well-being as they age.
Eventually, the findings from this study may help improve approaches for supporting brain health, memory, and healthy aging in older adults.
You may be eligible for this study if you meet the following criteria.
Inclusion Criteria:
- Men ages 60–85
- Identify as a person of color (Asian, Black, Latino)
- Live in the Oklahoma City area
- Normal kidney and liver function
Exclusion Criteria:
- Diagnosed with dementia or cognitive impairment
- Diagnosed with a central nervous system disease (e.g., Parkinson’s disease, Multiple Sclerosis, seizure disorder)
- Currently treated for or have active cancer
- Had a stroke within the past 60 days
The entire study lasts 8 weeks. Once enrolled, the study involves:
In the lab: 2 visits—one at the start and one after 8 weeks of taking daily study pills (either Nicotinamide Riboside or identical placebo). During each visit, participants will complete non-invasive measurements including:
Tablet-based cognitive games
Ultrasound scans of a forearm blood vessel
Thermal scans to assess finger temperatures
Video imaging of blood vessels under the tongue using a small probe
Scalp measurements of electrical activity, oxygenation, and blood flow with a specialized cap
Blood samples
Optional retinal imaging (if comfortable)
From home: Participants take daily study pills for 8 weeks. All procedures are non-invasive, safe, and designed to explore how Vitamin B3 (Nicotinamide Riboside) supports vascular and cognitive health. NR is generally well-tolerated with minimal side effects in human studies.
As a participant, you may receive $100.00 for each visit completed for a total of $200.00.
There is no cost for you to participate in our research study.