Depression Research Study
Researchers at Emory University are conducting a research study on new treatment options for adults with depression who may have high inflammation.
Fast Facts
Experiencing symptoms of depression
Not taking psychiatric medications
Ages 25-65
Conducted in
Atlanta, GA
Study Background
This study is evaluating how inflammation may impact depression and response to treatment.
Depression affects millions of adults and can look different from person to person. Emerging research suggests that inflammation in the body may play a role in certain subtypes of depression. By better understanding this connection, researchers hope to improve how treatments are selected and personalized.
This 8 week study will evaluate the effects and optimal dose of an FDA approved medication that may benefit individuals with depression and elevated inflammation. Participants will complete medical, psychiatric, and cognitive assessments, along with lab testing and functional MRI scans, to help researchers better understand how the treatment works in the brain and body.
Study Background
This study is evaluating how inflammation may impact depression and response to treatment.
Depression affects millions of adults and can look different from person to person. Emerging research suggests that inflammation in the body may play a role in certain subtypes of depression. By better understanding this connection, researchers hope to improve how treatments are selected and personalized.
This 8 week study will evaluate the effects and optimal dose of an FDA approved medication that may benefit individuals with depression and elevated inflammation. Participants will complete medical, psychiatric, and cognitive assessments, along with lab testing and functional MRI scans, to help researchers better understand how the treatment works in the brain and body.
Additional Information
This study is being conducted to determine the most effective dose of an FDA approved medication for individuals with depression who may have high inflammation, and to better understand how inflammation affects depression.
You may be eligible for this study if you meet the following criteria.
Inclusion Criteria:
- Ages 25-65
- Experiencing symptoms of depression
- Not taking psychiatric medications (e.g., antidepressants, mood stabilizers) or regularly taking anti-inflammatory medications (e.g., ibuprofen, aspirin)
- Struggling with low motivation
- Not using recreational drugs (e.g., cannabis, opioids)
- If female, not pregnant
- Not diagnosed with hepatitis A, B, or C
- Able to undergo MRI scan (no metal in the body, no claustrophobia)
- Have not been diagnosed with an autoimmune disorder
- Have not been diagnosed with a psychotic disorder (e.g., schizophrenia, bipolar I with psychotic features)
- Have not been diagnosed with a neurological disease (Parkinson’s, Alzheimer’s, dementia)
Participation lasts about 2 months and includes 2 to 3 screening visits, some online and some in person.
If eligible, participants will:
Complete medical and psychiatric evaluations
Provide blood samples for lab testing
Participate in neurocognitive testing
Undergo functional MRI (fMRI) brain scans
Attend scheduled study visits over the 8 week period
Participants can receive approximately $1,000 for completing the full study. An additional $50 per visit will be provided to help cover travel expenses for participants who travel 50 miles or more one way.
There is no cost for you to participate in our research study.