The purpose of this research study is to see how a meditation-based intervention affects pain. Specifically, we are interested in understanding the pain-relieving brain mechanisms of meditation-based therapy for patients with opioid-treated chronic low back pain.

You may be eligible for this study if you meet the following criteria.

Inclusion Criteria:

• 18-65 years old
• Chronic lower back pain: at least half the days in the last 6 months
• Have been prescribed opioid medication (e.g., tramadol, oxycodone, hydrocodone) for at least 3 months
• Interested in meditation-based therapy

Exclusion Criteria:

• Any prior experience with mindfulness-based interventions (such as MBSR, MBCT, MORE, or extensive involvement in standardized meditation training)
• Cancer related pain
• Suicidal ideation
• Psychosis in the past 6 months
• Pregnancy
• MRI contraindications (claustrophobia, metal in body)
• Abnormal MRI scan in the past

Participation in this study will include 13 study visits and at least one MRI brain scan.

As a participant, you can receive up to $600 for your time and effort.

There is no cost for you to participate in our research study.