The purpose of this study is to evaluate the differences between smoking and vaping dry-herb cannabis, and the differences between smoking cannabis and smoking tobacco cigarettes.

You may qualify for a study if you meet the following criteria.

Inclusion Criteria:

• Ages 21-70
• Current regular user of cannabis who smokes cannabis in any form, including joints, pipes, and blunt at least once a week for the past 3 months
• History of cannabis vaporizer use or willingness to use the vaporizer in the study
• Test positive for D-9-tetrahydrocannabinol (THC) at screening and self-report of cannabis use
• Current tobacco cigarette use who smokes ≥3 cigarettes per day

Exclusion Criteria:

• Unstable medical conditions, such as:

  • Heart disease
  • Seizures
  • Cancer
  • Thyroid disease (okay if controlled with medication)
  • Diabetes
  • Hepatitis B or C or Liver disease
  • Glaucoma
  • Kidney disease or urinary retention
  • An ulcer in the past year
  • Active use of an inhaler for asthma or COPD
  • Hypertension if uncontrolled (meaning participant has a diagnosis, but they are not taking medication/under treatment (e.g., diet or exercise plan)

Once enrolled, the study involves:

• One screening visit
• One orientation visit
• 6 outpatient hospital visits (2 days back-to-back), 3 weeks in a row
  • During those weeks, the participant will be randomized to one of the following
    • smoking tobacco cigarettes
    • smoking cannabis (joints)
    • vaping dry-herb cannabis.

Compensation is provided up to $2,150 for your participation.

There is no cost for you to participate in our research study.