This study is being conducted to better understand how different treatments impact insomnia and its related health outcomes, particularly blood pressure.

Insomnia is a common condition that not only disrupts sleep, but is also linked to serious health issues, like hypertension and cardiovascular problems. By studying the effects of Cognitive Behavioral Therapy for Insomnia (CBT-I) and trazodone, researchers aim to determine how these treatments can improve sleep quality and reduce health risks associated with poor sleep.

The research also seeks to explore whether specific insomnia phenotypes—such as variations in sleep duration—respond differently to these treatments. The findings could help personalize insomnia care, making it more effective for individuals based on their unique sleep patterns and health needs.

You may be eligible for this study if you meet the following criteria.

Inclusion Criteria:

• Ages 18+
• Experience difficulty sleeping 3+ days per week and more than 3 months
• Not currently using insomnia medication regularly
• No shift work or untreated sleep apnea
• Have regular access to the internet
• Open to behavioral and medication treatments for insomnia

If you participate in the SONO Study, you will undergo a series of assessments, treatments, and follow-ups designed to understand and improve your sleep and overall health.

Initial Screening

First, you will complete an in-person screening at the research facility, which includes measurements like blood pressure, clinical interviews, and possibly a pregnancy test if applicable.

Sleep Monitoring

At home, you’ll monitor your sleep using a diary and wrist activity tracker for one week, as well as measure your blood pressure daily for one week. You will also participate in overnight sleep studies at a lab to gather detailed sleep data.

Treatment

Next, you’ll engage in an 8-week Cognitive Behavioral Therapy for Insomnia (CBT-I) program through sessions that can be done virtually or in person. If further treatment is needed, you may join a randomized, placebo-controlled trazodone trial for an additional 8 weeks.

Additional Tasks

Throughout the study, you’ll complete home-based tasks, such as sleep diaries and activity monitoring, and return for follow-up assessments, including a six-month check-in after your last treatment.

All of these steps aim to evaluate how these treatments affect your sleep, blood pressure, and overall well-being.

Participants will receive up to $600, depending on the number of assessments they are required to complete. Participants are paid as follows:

• Pre-Treatment Visit should be $75

• CBT-I Post-Treatment Visit should be $150

• RCT Post-Treatment Visit should be $150

• Follow-Up Visit should be $100

• All applicable study visits should be $75

There is no cost for you to participate in our research study.